Self-crosslinked chitosan/dialdehyde xanthan gum blended hypromellose hydrogel for the controlled delivery of ampicillin, minocycline and rifampicin

The design of improved biopolymeric based hydrogel materials with high load-capacity to serve as biocompatible drug carriers is a challenging task vital implications in health sciences. In this work, chitosan crosslinked dialdehyde xanthan gum interpenetrated hydroxypropyl methylcellulose gels were developed for the controlled delivery different antibiotic drugs including ampicillin, minocycline and rifampicin. prepared scaffolds characterized by rheology method, FTIR, SEM, TGA compression analysis. addition, gelation kinetics, swelling, vitro degradation release rate studied under simulated gastrointestinal fluid conditions pH 2.0 7.4 at 37 °C. Results demonstrated gel composition structure affected kinetics. study showed more than 50% cumulative within 24 h all investigated drugs. cell cytocompatibility using mouse embryonic fibroblast lines depicted ?80% viability, indicating are non-toxic. Finally, antibacterial activity loaded was evaluated against Gram-negative positive bacteria ( Escherichia coli , Staphylococcus aureus Klebsiella pneumonia ), which correlated well swelling results. Overall, present that produced serves promising material towards microbial growth inhibition. • Self-crosslinked chitosan/xanthan hypromellose hydrogels developed. Hydrogels good mechanical stability pore distribution. rifampicin release, biocompatibility activity.